| Hyseq, Inc. announced today that it has filed a registration statement on Form S-1 with the Securities and
 Exchange Commission for an initial public offering of 2,750,000 shares of its
 Common Stock, all of which will be sold by the Company.  The filing covers an
 additional 412,500 shares that will be subject to the underwriters'
 overallotment option.  The Company expects the shares to come to market
 between $12 and $14 per share.  Lehman Brothers Inc., Smith Barney & Co. Inc.,
 and Fahnestock & Co. Inc., will manage the offering.
 Hyseq, Inc. applies the proprietary DNA array technology of its integrated
 HyX(SM) genomics platform to develop gene-based therapeutic product candidates
 and diagnostic products and tests.
 The Company anticipates that the net proceeds of the offering will be used
 to develop potential therapeutic product candidates and diagnostic tests,
 expand the HyGenomics(TM) Database, further develop the HyChip(TM) Module,
 invest in capital equipment and lease additional space to increase capacity
 and general corporate purposes, including working capital.
 A registration statement relating to these securities has been filed with
 the Securities and Exchange Commission, but has not yet become effective.
 These securities may not be sold nor may offers to buy be accepted prior to
 the time the registration statement becomes effective.  This communication
 shall not constitute an offer to sell or the solicitation of an offer to buy
 nor shall there be any sale of the securities in any State in which such
 offer, solicitation or sale would be unlawful prior to registration or
 qualification under the securities laws of any such State.
 Copies of the prospectus contained in the Registration Statement may be
 obtained by written or oral request directed to Lehman Brothers Inc., c/o ADP
 Processing, 536 Broadhollow Road, Melville, Long Island, New York at
 516-254-7106 and by facsimile at 516-249-7942.
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