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Strategies & Market Trends : World Outlook

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To: Les H who wrote (17763)	1/10/2018 12:19:28 PM
From: Les H	of 50338

Study: Metformin Linked to Higher Risk of Alzheimer’s and Parkinson’s diabetesdaily.com Dr. Kuan told Medscape they adjusted for age, sex, and diabetes severity and that despite this, “the cumulative incidences of Parkinson’s and dementia were significantly higher for our metformin cohort” at 12 years. In fact, the risk for Parkinson’s disease or Alzheimer’s dementia went up over 50 percent during a 12 year period in those who took metformin when compared to those who did not. Researchers also found that “outcome risks increased progressively with higher dosage and longer duration of treatment.” Dr. Yi-Chun Kuan said, “We’d heard about a possible protective effect from metformin. However, we found the reverse,” and she added that large-scale, prospective studies would need to be done in other countries to get clarification of the results. Another detail the researchers noted was that outcomes increased the longer a patient was on metformin and the higher the metformin dose they took, “especially with use for more than 300 days and doses greater than 240 g.”

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