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Biotech / Medical : Biotech Valuation

CRSP 58.15

+5.4%

3:59 PM EST

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To: Ian@SI who wrote (20800)	8/10/2006 6:42:18 PM
From: DewDiligence_on_SI	of 52153

Lucentis is a monthly shot in the eye with a very sharp stick; the Briefing clip said RNAI's tx was a single dose. If that's the case both Retinal Specialists and patients will opt for shot, all else equal. Patients will need repeat dosing to maintain an improvement in vision: investorshub.com This is a good start, but there is much work left to do. Open-label AMD trials should be looked at with skepticism. An improvement in visual acuity relative to baseline could result from such a seemingly minor variation as a patient leaning forward in the chair while reading the eye chart. As Tuck mentioned, GENR is a case in point. GENR’s early, open-label data were similar to (actually slightly better than) RNAI’s, yet GENR has been unable to replicate the early data in any randomized trials to date.

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