| PNU is on everyone's list of merger candidates.  Reuters came out with another story just before after 11:00 AM: 
 Britain's Zeneca -- lonely near the top?
 
 By Jonathan Birt
 LONDON, Feb 2 (Reuters) - Within five years of its demerger
 from ICI ICI.L, Zeneca Group Plc ZEN.L Group Plc is on the
 brink of becoming Britain's second largest drugs company, with a
 market value three and half times that of its former parent.
 But suddenly number two looks an uncomfortable place to be,
 even with a capitalisation of more than 23 billion pounds ($37.8
 billion) to protect you, if the number one spot is to be held by
 a monolith of Glaxo Wellcome GLXO.L/SmithKline Beecham Plc
 SB.L proportions.
 Based on 1996 figures, Zeneca's prescription drug sales of
 $3.8 billion are dwarfed by Glaxo/SmithKline's $20 billion
 tally, while a global market share of around 1.5 percent pales
 beside one of more than seven percent.
 Some analysts believe companies of Zeneca's size are
 vulnerable in the high budget areas of marketing and especially
 in drug research and development.
 The group's 1996 drug spend of less than $700 million
 compared with a combined $2.8 billion for Glaxo/ SmithKline, and
 Zeneca has only partially allayed fears that it faces a gap
 between expiring products and new drugs early next century.
 "With a Glaxo/SmithKline merger, Zeneca is vulnerable in a
 lot of its primary markets," UBS analyst Jerry Brimeyer said.
 "They need to do something pretty fast to deal with the gap
 in the pipeline...to acquire new products, and they need to look
 at their position in the world ranking," Greig Middleton analyst
 Tim Franklin added.
 But the group's widely admired and phlegmatic chief
 executive Sir David Barnes, whose contract runs until 1999, has
 always resisted a merger, turning away a host of supplicants,
 including both Upjohn and Pharmacia PNU.N before their linkup.
 Barnes argues that leadership in therapeutic categories is
 more important than overall market share.
 One analyst, who asked not to be identified, said Barnes'
 stance was justified.
 "If you can keep on growing earnings at 15 percent every
 year then you shouldn't have to go and jump into bed with
 somebody else. They have got two very strong niches in
 cardiovascular and cancer, and they have critical mass in
 agrochemicals," he said.
 But others believe Zeneca will opt to find a partner, either
 this year under Barnes' leadership or soon after his departure.
 The inexorable rise of the group's share price, which has
 climbed by 186 percent over the past three years, partly
 reflects the markets view of it as a takeover -- and now more
 realistically, a merger -- candidate.
 Rumours of interest from Switzerland's Roche Holding AG
 ROCZg.S, itself increasingly left behind by the formation of
 domestic rival Novartis AG NOVZ.S and now Glaxo/SmithKline,
 have eased but never really gone away.
 Sweden's Astra AB ASTRa.ST is also mooted as a strong fit.
 Astra Zeneca, as well as being a graphic designer's gift, would
 bring together two groups of similar size, broadening the
 therapeutic range and offering mutual benefits in areas like
 asthma, cardiovascular drugs and pain control.
 Both also have strong UK research bases -- Zeneca in
 north-west England and Astra at the former Fisons site in
 central England.
 "Astra and Zeneca would make great bedfellows if they ever
 got around to it," said Dresdner Kleinwort Benson analyst Peter
 McDougall, who believes the UK group will not be independent by
 the end of the year.
 A Zeneca/Astra merger however would face the problem of
 Astra's U.S. joint venture with Merck and Co Inc MRK.N & Co,
 which many analysts regard as disadvantageous to the Swedish
 group.
 It would also leave both companies without critical sales
 mass in the crucial U.S. market, whose strong growth has
 underpinned the sector while budgetary restraint has hit
 European spending.
 In the U.S., there has been speculation that SmithKline's
 abandoned partner American Home Products Corp AHP.N would make
 a good fit with Zeneca.
 UBS' Brimeyer said an AHP/Zeneca deal would         pcfhub04        produce "a
 complimentary product mix. Zeneca, with its cancer and migraine
 drugs, and American Home, with its franchise in women's health
 and arthritis drugs, would be very well positioned among general
 practitioners and specialists."
 
 
 ($ = 0.608 British Pounds)
 REUTERS
 Rtr 11:04 02-03-98
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