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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ)
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To: Bull-like who wrote (2601)11/20/1997 8:47:00 AM
From: Bradpalm1  Read Replies (1) of 23519
 
Bull-like,

I think I partially answered my own question. PGE-1&2, forskolin and VIP are DIRECT activators of adenylate cyclase which in turn increases cAMP and doesn't require mediation through PDE isoenzymes. Nitric oxide, on the other hand, directly activates guanylate cyclase and increases cGMP via an analogous mechanism. Inhibition of PDE III, IV & V isoenzymes would still seem to result in penile smooth muscle relaxation although it appears that PDE V is more specific to this area. Doesn't papaverine act as a nonspecific PDE inhibitor?

Great news about FDA recertification (cGMP, not the other cGMP). UK approval is next.

Bradpalm1
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