My guess is that it's both excitement over a gene-regulation deal, and something related to this............
Medline ID:
96185499
Citation:
Taunton J, Hassig CA, Schreiber SL, A mammalian histone
deacetylase related to the yeast transcriptional regulator
Rpd3p [see comments], Science 272: 5260, 408-11, Apr
19, 1996.
Address:
Howard Hughes Medical Institute
Harvard University
Cambridge
MA 02138
USA.
Abstract
Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo
and causes mammalian cells to arrest in the cell cycle. A trapoxin affinity matrix was used
to isolate two nuclear proteins that copurified with histone deacetylase activity. Both
proteins were identified by peptide microsequencing, and a complementary DNA encoding
the histone deacetylase catalytic subunit (HD1) was cloned from a human Jurkat T cell
library. As the predicted protein is very similar to the yeast transcriptional regulator Rpd3p,
these results support a role for histone deacetylase as a key regulator of eukaryotic
transcription.
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wild guess, no rumor, no fact...........
Rick |
