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Biotech / Medical : AutoImmune-AIMM
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To: organ who wrote (48)3/18/1997 9:45:00 AM
From: Biomaven   of 298
 
Any comments on the following article:

The Journal of NIH Research
03/01/97

Oral Tolerance: Feeding Autoantigens Can Exacerbate Rather Than Ameliorate Autoimmune Disease
William R. Heath and Jacques F.A.P. Miller*

Abstract: It has been known for many years that administering an antigen orally can induce immunological tolerance, in which the immune system ceases to recognize and/or respond specifically to the antigen. This has led to the use of oral-antigen delivery for the treatment of human autoimmune diseases such as rheumatoid arthritis and multiple sclerosis--an approach also recently proposed for autoimmune diabetes (also called type 1, or insulin-dependent, diabetes). Despite the long interest in oral tolerance, very little is known about the precise mechanisms by which it operates. In an attempt to elucidate the mechanism of oral tolerance, we have generated several lines of transgenic mice based on the use of ovalbumin (OVA) as an autoantigen in a diabetes model. Using such mice, we have found that feeding autoantigen can cause--rather than prevent--autoimmunity, perhaps by stimulating cytotoxic T cells against the orally administered antigen through a cross-presentation pathway. Our observations raise a strong note of caution regarding the indiscriminate use of oral-antigen administration in treating human autoimmune diabetes and other autoimmune diseases.

The full text is available at:
enews.com:80/magazines/nih/current/970301-004.html
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