| Anergen Reports First Quarter 1998 Results 
 REDWOOD CITY, Calif., April 16 /PRNewswire/ -- Anergen, Inc. (Nasdaq: ANRG - news) today reported a net loss of
 $2,078,000, or $0.11 per share, for its first quarter ended March 31, 1998, as compared to a net loss of $1,824,000, or
 $0.10 per share, for the comparable quarter ended March 31, 1997.
 
 ''Spending in the first quarter of 1998 is in line with our plan for the year,'' said David V. Smith, Vice President, Finance and
 Chief Financial Officer. ''The first quarter results were influenced by lower expenses as a result of the conclusion of our Phase
 IIa trial of AnervaX(TM) for rheumatoid arthritis and we are nearing completion of our Phase I trial of AnergiX(TM) for
 multiple sclerosis. This was offset by increased research and development activity related to the filing of an IND for AnergiX in
 rheumatoid arthritis in collaboration with N.V. Organon.''
 
 Anergen, Inc. is a biotechnology company focused on advancing the treatment of autoimmune diseases. It is developing
 proprietary biopharmaceutical compounds designed to selectively interrupt antigen presentation or inactivate T cells in the
 immune system that mediate the disease process.
 
 Note: Certain statements in this press release about the Company's utilization of resources, product development activities,
 clinical trials and product pipelines, other than statements of historical fact, are forward- looking statements, and are made
 pursuant to the Safe Harbor Provisions of the Private Securities Litigation Reform Act of 1995. Such statements involve risks
 and uncertainties. The Company's actual results could differ materially from the results discussed in these forward-looking
 statements. Factors that could cause or contribute to such differences include dependence upon collaborative partners for the
 advancement of the company's research and development activities, uncertainties related to preclinical and clinical trials,
 government regulation; no assurance of obtaining product approvals and future requirements for additional capital. These items
 are discussed in the Company's Form 10-K filed for fiscal year 1997 and the reports filed on Form 10-Q.
 
 Selected Financial Data
 (In thousands except per share data)
 
 Operations data
 Three months ended
 March 31,
 1998           1997
 
 Revenues:
 Contract revenues                                $1,167        $ 1,808
 Interest income                                     115            182
 1,282          1,990
 Expenses:
 Research and development                          2,482          2,887
 General and administrative                          837            884
 Interest expense                                     41             43
 3,360          3,814
 Net loss                                          $2,078         $1,824
 Net loss per share                                 $0.11          $0.10
 Shares used in calculating per share data         18,851         18,781
 
 Balance sheet data
 March 31,    December 31,
 1998           1997
 (Unaudited)
 
 Cash, cash equivalents & ST investments           $6,750        $ 8,403
 Accounts receivable                                   60            333
 Working capital                                    4,931          6,918
 Total assets                                       8,409         10,554
 Total liabilities                                  2,696          2,767
 Shareholders' equity                               5,713          7,787
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