MELA Sciences        Collaborates With Columbia University Imaging Experts
  Columbia        Team to Explore Potential Next Generation MelaFind Enhancements
  IRVINGTON,        N.Y., Aug. 26, 2014 (GLOBE NEWSWIRE) --        MELA Sciences,        Inc. (Nasdaq:MELA), developer of the MelaFind(R) system, a non-invasive        optical diagnostic tool that assists dermatologists in the diagnosis of        melanoma at its most curable and cost-effective stage and that has        received both FDA Pre-Market Approval (PMA) for the U.S. and CE Marking        certification for the European Union, today announced it has executed a        research agreement with Columbia University in which        MELA and        Columbia will collaborate to explore potential next generation        capabilities and features of the MelaFind system and other enhancements        to the system's range and ease of use.
  The Columbia team, led by        Principal Investigator Andreas H. Hielscher, Ph.D., will utilize certain        proprietary Columbia technology within its scope of work. The company        will have exclusive rights to license any intellectual property that may        result from the research collaboration.
  "This is a rare        opportunity to engage some of the best minds in the world to study the        MelaFind system and potentially develop the next generation of imager        that will provide a more powerful solution in support of early detection        and life-saving treatment for melanoma," said Rose Crane,        MELA Sciences        President and CEO. "We are excited about the prospect of working with        Dr. Hielscher and his team."
  About the Columbia Research Team
  Dr.        Andreas H. Hielscher is a Professor of Biomedical Engineering,        Electrical Engineering and Radiology at Columbia University. He focuses        on optical medical instrumentation and image reconstruction algorithms        and has conducted clinical and preclinical imaging of joint diseases,        cancer, cerebral hemodynamics and vascular reactivity. Dr. Hielscher and        his team at the Biophotonics and Optical Radiology Laboratory at        Columbia possess considerable experience in modeling of light        propagation in tissue and designing optical medical instrumentation.
  About        MelaFind www.melafind.com
  MelaFind is the first and only medical        device with FDA Pre-Market Approval (PMA) for the U.S. and CE Marking        certification for the European Union designed to assist dermatologists        in the evaluation and diagnosis of melanoma at its most curable and        cost-effective stage. The MelaFind(R) system utilizes innovative        software driven technology and state-of-the-art 3-D optical imaging to        non-invasively extract data 2.5 mm below the skin surface from patient's        pigmented ambiguous moles and objectively analyzes them with proprietary        algorithms. MelaFind provides important additional perspective to        physicians via 3-D spectral images and 100% objective data analysis to        help them better understand the structural disorganization of a        patient's pigmented ambiguous moles (before cutting the skin) during the        evaluation and diagnosis process for melanoma.
  About        MELA Sciences,        Inc. www.melasciences.com
  MELA        Sciences        is a medical technology company dedicated to designing and developing        innovative software-driven technology for the clinical early detection        and prevention of skin cancer.        MELA Sciences        conducted the largest, positive prospective study ever done on the        melanoma disease, and is the first and only medical technology company        to receive both FDA Pre-Market Approval (PMA) for the U.S. and CE        Marking certification for the European Union for a device of this nature.
  Safe        Harbor
  This press release includes "forward-looking statements"        within the meaning of the Securities Litigation Reform Act of 1995.        These statements include but are not limited to our plans, objectives,        expectations and intentions and may contain words such as "seeks," "look        forward," and "there seems" that suggest future events or trends. These        statements are based on our current expectations and are inherently        subject to significant uncertainties and changes in circumstances.        Actual results may differ materially from our expectations due to        financial, economic, business, competitive, market, regulatory and        political factors or conditions affecting the company and the medical        device industry in general, as well as more specific risks and        uncertainties set forth in the company's SEC reports on Forms 10-Q and        10-K. Given such uncertainties, any or all of these forward-looking        statements may prove to be incorrect or unreliable.        MELA Sciences        assumes no duty to update its forward-looking statements and urges        investors to carefully review its SEC disclosures available at        www.sec.gov and www.melasciences.com.
  CONTACT: Media Diana Garcia        Redruello MELA Sciences,        Inc. 212-518-4226 dgarcia@melasciences.com Investors Andrew McDonald,        Ph.D LifeSci Advisors, LLC 646-597-6987 andrew@lifesciadvisors.com      |