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United States Patent 4,923,442
Segall, et. al. May 8, 1990
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Blood substitute Inventors: Segall; Paul E. (Berkeley, CA); Waitz; Harold D. (Berkeley, CA); Sternberg; Hal (Berkeley, CA).
Assignee: Cryomedical Sciences Inc. (Bethesda, MD).
Appl. No.: 343,850
Filed: Apr. 26, 1989
Related U.S. Application Data
Continuation-in-part of Ser No. 189,011, May 2, 1988.
Intl. Cl. : A61K 31/70, A61K 53/06, A61K 33/14, A61K 31/715
Current U.S. Cl.: 604/52; 128/897; 128/898; 424/677; 424/679; 424/680; 424/681; 424/682; 424/692; 514/23; 514/56; 514/59; 604/49; 604/51
Field of Search: 424/677, 679, 680, 681, 682, 692; 524/23, 56, 59; 128/897, 898; 604/49, 51, 52, 53
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References Cited | [Referenced By]
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Other References
Kelbanoff et al. "Temporary Suspension of Animation Using Total Body Perfusion and Hypothermia", Cryobiology 6(2) 1969, pp. 121-125.
Haff et al., "Asanguineous Hypothermic Perfusion as a Means of Total Organism Preservation", J. of Surg. Res. 19, 1975, pp. 13-19.
Belzer et al., "Combination Perfusion-Cold Storage for Optimum Cadaver Kidney Function & Utilization", Transplantation 39(2) 1985, pp. 118-121.
Wall et al., "Simple Hypothermic Preservation for Transporting Human Livers Long Distances for Transplantation", Transplantation 23(3), 1977, pp. 210-216.
Gan et al., "Ice Cold Blood-Substituted Hamsters Revive", Federation Proceedings 44(3): 623 (1985).
Primary Examiner: Brown; Johnnie R.
Assistant Examiner: Witz; Jean C.
Attorney, Agent or Firm: Fineman; Elliott L.
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Abstract
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A blood substitute suitable for replacing blood in mammalian subjects when performance of surgical procedures at hypothermic temperatures is described. The blood substitute comprises water, electrolytes at physiological concentration, dextran 40 at a concentration sufficient for the blood substitute to achieve a colloidal suspension having a fluid osmotic pressure essentially equivalent to mammalian plasma, HEPES buffer at a physiological pH, dextrose, magnesium ion at a concentration of about 0.01M and potassium ion at a concentration greater than 10 mEq per liter sufficient to prevent or arrest cardiac fibrillation. In one embodiment the blood substitute is a multi-solution system wherein the solutions comprise differing levels of the above-indicated componants and are administered sequentially to completely replace a subjects circulating blood.
26 Claims, No Drawings
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