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Biotech / Medical : Biotechnology Value Fund, L.P.

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To: scaram(o)uche who wrote (93)4/11/1998 12:25:00 AM
From: scaram(o)uche of 4974
 
[ CVAS, BVF ups stake ]

ITEM 3. SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION.

Since February 8, 1998, Partners, in its capacity as general partner of
BVF, has purchased on behalf of such limited partnership an aggregate number
of 248,579 shares of the Stock for an aggregate consideration of
$1,110,278.50, utilizing funds provided by BVF from its working capital
pursuant to the terms of its limited partnership agreement with Partners. In
addition, Partners, in its capacity as investment manager with respect to
certain managed accounts, has purchased on behalf of such managed accounts an
aggregate number of 389,308 shares of the Stock for an aggregate
consideration of $1,727,254.25, utilizing funds under management by Partners
pursuant to investment management agreements between Partners and such
managed accounts.

Item 5 is hereby amended to read in its entirety as follows:

ITEM 5. INTEREST IN SECURITIES OF THE ISSUER.

(a) BVF beneficially owns 934,606 shares of the Stock, Partners
beneficially owns 1,928,143 shares of the Stock, and BVF Inc. beneficially
owns 1,928,143 shares of the Stock, approximately 6.7%, 13.8% and 13.8%,
respectively, of the aggregate number of shares outstanding as of March 18,
1998 (as reported in Corvas' annual statement on Form 10-K).
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