United States Patent Application 20030054402
Kind Code A1
Klein, Christine A. ; et al. March 20, 2003
--------------------------------------------------------------------------------
Methods and compositions for identifying receptor effectors
Abstract
The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screening of large numbers of polypeptides in a library to identifying those polypeptides which induce or antagonize receptor bioactivity. The subject assay is particularly amenable for identifying surrogate ligands for orphan receptors.
--------------------------------------------------------------------------------
Inventors: Klein, Christine A.; (Ossining, NY) ; Murphy, Andrew J.M.; (Croton on the Hudson, NY) ; Fowlkes, Dana M.; (Chapel Hill, NC) ; Broach, James; (Princeton, NJ) ; Manfredi, John; (Ossining, NY) ; Paul, Jeremy; (Nyack, NY) ; Trueheart, Joshua; (Nyack, NY)
Correspondence Name and Address: LAHIVE & COCKFIELD
28 STATE STREET
BOSTON
MA
02109
US
Assignee Name and Adress: Cadus Pharmaceutical Corporation
Serial No.: 953354
Series Code: 09
Filed: September 13, 2001 |
