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Biotech / Medical : Agouron Pharmaceuticals (AGPH)

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To: JOHN W. who wrote (1060)7/28/1997 7:03:00 PM
From: David S.   of 6136
 
Although I am neither long or short AGPH, I offer the following (just like Walter Cronkite):
Subject:
Switched to Viracept and failed...
Date:
Mon, 21 Jul 1997 00:26:55 -0400
From: (removed for privacy)

Reply-To:
Crixivan E-Mail Discussion List <Crix-List@PinkPage.com>
To:
"Crix List" <Crix-List@PinkPage.com>

After 6 months on Crix, 3TC, and D4T my viral load was undetectable, but I changed to Viracept because of kidney sludge and other drug side effects. My doctor felt it was OK to switch just one drug with undetectable viral load. At 6 weeks on this new combo (Viracept, 3TC, and D4T) my viral load was 2,500. We re-checked it but the 2nd viral load was 18,000!

So, what to take now? Doctor's answer - Saquinivir with Viracept (to
increase blood levels of Saq), add DDI and keep the D4T. Of course I'm on Bactrim too so this means I'll be taking 34 pills a day! I haven't started yet (will pick up the Saq tomorrow) but am rather intimidated by the complicated schedule (DDI - 2 X day on empty stomach, Viracept - 3 X day with food) and the huge number of pills (Saq alone is 18 - 6 pills 3 X day). I'm also worried about peripheral neuropathy with the two "D" drugs.

Yes, Johnnie, I am aware of the side-effect reports on that discussion list, but just posting that wouldn't be...educational. Did you still want to take me out to dinner when I'm in New England?
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