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Biotech / Medical : Northfield Lab(NFLD)
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To: borb who wrote (117)3/25/2002 7:38:37 PM
From: Archie Meeties  Read Replies (1) of 148
 
BPUR's recent pIII trial results leave open the question of the mechanism for vasocontriction. Was it immune mediated? If so, one could speculate that the posted study's absence of immune response would give NFLD an advantage over hemopure. One holy grail in ICU medicine has been the control of the immune response to sepsis and subsequent SIRS. That The NFLD blood showed no increase in neutrophil activity vs. blood would make it preferable in sepsis, which is by itself not usually a reason for transfusion, although if you go into DIC that's a different story. I would hazard that the overlap between SIRS and trauma-shock-end organ damage would be sufficient for immune response to be a HUGE issue for BPUR if indeed their rise in blood pressure is immune mediated. Why the stock went up because of a 17mmHG rise in blood pressure over 30min I have not freakin' clue. I'd like to see the variance in that bp rise- I'd bet there were some folks in whom hemopure was more antigenic and that it cause a much higher rise in bp. BTW, the fact that hemopure causes an acute rise in bp absolutely rules it out for use in a trauma patient with head injury. I don't know the stat off hand, but that's probably upward of 15% of all trauma patients. The BPUR study, of course, was in orthopedic patients. But a good blood substitute needs to be used in trauma, and other critical uses, not run of the mill scheduled orthopedic surgery. I don't see the big benefit with a few less transfusion when you need it post op.
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