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Biotech / Medical : NNVC - NanoViricides, Inc.
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From: donpat3/28/2006 7:04:57 AM
   of 12873
 
Vaccine against bird flu

Tuesday, 28th March 2006, 07:39
Category: Healthy Living

LIFE STYLE EXTRA (UK) - SCIENTISTS have created a vaccine against bird flu using horse antibodies.

The Chinese researchers managed to cure mice after infecting them with the killer H5N1 virus.

They discovered the antibodies - derived from horses - prevented the animals from dying.

The study published in the journal Respiratory Research showed a dose of 1O,OOOth of a gram of the horse anti-serum effectively protected the infected mice.

The scientists hope the anti-H5N1 antibodies developed in horses could potentially be used to save dying human bird flu victims or as early treatment for the disease.

Dr Jiahai Lu, of Sun Yat-Sen University in Guangzhou, China, and colleagues infected dog kidney cells in the lab with a lethal dose of H5N1 and simultaneously exposed the
cells to horse antibodies against H5N1.

The cells simultaneously infected with H5N1 and exposed to horse antibodies did not die.

The scientists then injected horse antibodies into 40 mice that had been
infected with a lethal dose of H5N1 24 hours earlier.

They also injected horse serum without H5N1 antibodies into a group of mice that acted as controls.

The researchers found 5,OOOth of a gram of antibody protected 70% of the mice
against death from bird flu and double the dose protected all the animals.

But the mice in the comparison group died nine hours after receiving the normal horse serum that did not contain the H5N1 antibodies.

Public health expert Dr Jiahai Lu said: "Until we have an efficacious vaccine, specific anti-H5N1 agents and effective epidemiologic control measures for H5N1 virus infection, highly mpathogenic H5N1 virus is likely to be a major health threat tto the world."

He said the vaccine could potentially be used for the early treatment of bird flu patients to reduce the severity of illness and the likelihood of passing on the virus to others.

The research had provided "experimental support" for using the vaccine in future large primate or human trials, said Dr Jiahai Lu.

Copyright © 2006 National News +44(0)207 684 3000

lse.co.uk
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