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Biotech / Medical : Geron Corp.

GERN 1.495

+9.5%

11:39 AM EST

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To: r. peter Dale who wrote (124)	8/16/1997 1:42:00 PM
From: maileg	of 3578

Hi Peter, thanks for the clarification. I also am not familiar with the current apoptosis literature, nor with the specificity of the TUNEL assay, although I do know that it is very commonly used now to detect apoptosis. I was just curious whether you were saying that the nicked "overhangs" are a phenomena that is common in non-apoptotic cancer cells, and that this doesn't necessarily lead to fragmentation. Or, you may have been indicating that DNA fragmentation is not a reliable indicator of apoptosis. If so, then you are correct that it complicates some research since detection of apoptotic cells is particularly crucial in experiments involving testing new apoptosis-inducing agents on cancer cells. Sorry for the non-relevent scientific discussion, guys... it just caught my eye and I had to ask. Darci

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