this year........
based upon the number of shares issued and outstanding as of April 12, 2002, plus shares of Common Stock subject to options and warrants held by such person on April 12, 2002 exercisable within sixty days thereafter. Except as otherwise indicated, to the knowledge of the Company, all persons listed below have sole voting and investment power with respect to their shares of Common Stock, except to the extent authority is shared by spouses under applicable law.
Name and Address of Beneficial Owner(1)
--------------------------------------------------------------------------------
Number of Shares
Beneficially Owned(2)
--------------------------------------------------------------------------------
Percentage of Shares
Beneficially Owned(2)
--------------------------------------------------------------------------------
Wells Fargo Bank Indiana, N.A.(3)
P.O. Box 960
Fort Wayne, IN 46801 3,419,015 14.4 %
Atlas Venture(4)
222 Berkeley Street, Suite 1950
Boston, MA 02116 2,564,151 10.9 %
Oxford Bioscience Partners(5)
315 Post Road West
Westport, CT 06880 2,092,863 8.9 %
CIBC(6)
425 Lexington Avenue, 9th Floor
New York, NY 10017 2,099,118 9.0 %
14
--------------------------------------------------------------------------------
Forward Ventures(7)
9255 Towne Centre Drive, Suite 300
San Diego, CA 92121 1,242,324 5.3 %
Joseph S. (Jay) Mohr 300 *
Taylor J. Crouch(8) 849,361 3.5 %
Anne L. Bailey(9) 145,811 *
Alan C. Houston, M.D.(10) 74,306 *
Richard P. Shea(11) 125,851 *
Vincent P. Stanton Jr., M.D.(12) 143,219 *
Colin W. Dykes, Ph.D.(13) 296,418 1.3 %
David Housman, Ph.D.(14) 288,391 1.2 %
Philippe O. Chambon, M.D., Ph.D.(15) 3,978,193 16.7 %
Jean-Francois Formela, M.D.(16) 2,595,301 11.0 %
William A. Scott, Ph.D.(17) 29,254 *
Martin A. Vogelbaum(18) 149,584 *
Ellen M. Zane(19) 18,334 *
All directors and current executive officers as a group (11 persons) 7,548,544 30.6 %
--------------------------------------------------------------------------------
last year.......
<CAPTION>
NUMBER OF SHARES PERCENTAGE OF SHARES
NAME AND ADDRESS OF BENEFICIAL OWNER(1) BENEFICIALLY OWNED(2) BENEFICIALLY OWNED(2)
- --------------------------------------- --------------------- ---------------------
<S> <C> <C>
Wells Fargo Bank Indiana, N.A.(3)....................... 3,419,015 14.4%
P.O. Box 960
Fort Wayne, IN 46801
Atlas Venture(4)........................................ 2,564,151 10.9%
222 Berkeley Street, Suite 1950
Boston, MA 02116
Oxford Bioscience Partners(5)........................... 2,115,363 9.0%
315 Post Road West
Westport, CT 06880
CIBC(6)................................................. 2,099,118 9.0%
425 Lexington Avenue, 9th Floor
New York, NY 10017
Forward Ventures(7)..................................... 1,242,324 5.3%
9255 Towne Centre Drive, Suite 300
San Diego, CA 92121
Taylor J. Crouch(8)..................................... 407,798 1.7%
Anne L. Bailey(9)....................................... 100,134 *
Colin W. Dykes, Ph.D.(10)............................... 126,160 *
Bruce L. Maloff, Ph.D.(11).............................. 36,257 *
Richard P. Shea(12)..................................... 79,323 *
</TABLE>
13
<PAGE>
<TABLE>
<CAPTION>
NUMBER OF SHARES PERCENTAGE OF SHARES
NAME AND ADDRESS OF BENEFICIAL OWNER(1) BENEFICIALLY OWNED(2) BENEFICIALLY OWNED(2)
- --------------------------------------- --------------------- ---------------------
<S> <C> <C>
David Housman, Ph.D.(13)................................ 256,619 1.1%
Philippe O. Chambon, M.D., Ph.D.(14).................... 3,965,904 16.8%
Jean-Francois Formela, M.D.(15)......................... 2,582,369 11.0%
William A. Scott, Ph.D.(16)............................. 15,377 *
Martin A. Vogelbaum(17)................................. 40,984 *
Anthony H. Wild, Ph.D.(18).............................. 108,877 *
Ellen M. Zane(19)....................................... 5,000 *
All directors and executive officers as a group (14 7,860,467 31.8%
persons)..............................................
</TABLE> |
