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Biotech / Medical : Biotech Valuation

CRSP 55.15

+2.5%

3:59 PM EST

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To: scaram(o)uche who wrote (14942)	12/26/2004 6:42:09 PM
From: Henry Niman	Read Replies (1) of 52153

Actually, influenza and all viruses evolve via recombination. Influenza does it more quickly than most viruses because there is quite a bit of variety and many dual infections. Science is still lagging in this area. Current dogma discusses shifts and drifts due to a polymerase without a proof reading function causing drifts via new mutations (leading to annual flu shots) and reassortment causing shifts (leading to pandemics). Although mutations and reassortment happens, new genes are created annually via recombination. It is the true driver of rapid evolution and emergence and the failure to recognize this simple underlying concept is why vaccine manufacturers are chasing the virus instead of making vaccines to viruses before they emerge. The sequences of the viruses provide the clues and the rules are extremely simple recombinomics.com You can talk about pandemics all you want, but without understanding how viruses emerge and evolve, the talk won't do much - the viruses don't read this board or press releases - they just follow some very basic rules that have worked quite well for billions of years. The situation in Korea has examples of all of the above - a virus that moved from a lab into pigs, reassorted with avian viruses, and then recombined to pick up swine sequences from swine viruses and create new genes by picking up polymoprhisms from the swine virus and making new avian / avian and human / avian genes. The situation is quite a teaching tool, but there still has been no announcement about 1933 human viruses in 2004 Korean swine. recombinomics.com

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