SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Biotech / Medical : MGNX -- MacroGenics
MGNX 1.660+4.1%Oct 31 9:30 AM EDT
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  
To: scaram(o)uche who wrote (160)2/19/2019 12:36:11 PM
From: Miljenko Zuanic1 Recommendation

Recommended By
scaram(o)uche

   of 188
 
You are right, 012 is hinge-stabilized ( ir.macrogenics.com ), and they did not at all mentioned any Fc-interaction modification.

On of world patent application (only ONE original) for MGNX anti-PD1 Abs:
worldwide.espacenet.com
from claims:
<(b) SEQ ID NOs: 264 and 267.
The anti-human PD-l-binding molecule of any one of claims 13-16, wherein said Fc Region is a variant Fc Region that comprises: (a) one or more amino acid modifications that reduces the affinity of the variant Fc Region for an FcyR; and/or
(b) one or more amino acid modifications that enhances the serum half-life of the variant Fc Region.
Claim 19. The anti-human PD-1 -binding molecule of claim 14, wherein said modifications that reduces the affinity of the variant Fc Region for an FcyR comprise the substitution of L234A; L235A; or L234A and L235A, wherein said numbering is that of the EU index as in Kabat.
Claim 20. The anti-human PD-l-binding molecule of claim 14 or 15, wherein said modifications that that enhances the serum half-life of the variant Fc Region comprise the substitution of M252Y; M252Y and S254T; M252Y and T256E; M252Y, S254T and T256E; or K288D and H435K, wherein said numbering is that of the EU index as in Kabat.>

World patents, claims 18-20:
worldwide.espacenet.com

So, what is true modification on 012....I have no idea!
Report TOU ViolationShare This Post
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  

HomeMailHotSubjectMarksPeopleMarksKeepersSettings
Terms Of UseContact UsCopyright/IP PolicyPrivacy PolicyAbout UsFAQAdvertise on SI
© 2025 Knight Sac Media.  Data provided by Twelve Data, Alpha Vantage, and CityFALCON News