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Biotech / Medical : PFE (Pfizer) How high will it go?
PFE 25.79-0.9%3:59 PM EST
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To: Early Out who wrote (1660)4/26/1998 3:52:00 PM
From: Brian Malloy   of 9523
 
The Viagra report you site if read carefully will show that for about 30% of patients Viagra just is not effective. For perhaps another 20% it works but not sufficiently to sustain the type of erection needed for orgasm. For 50% or so it works just fine and undoubtedly should be the drug of choice. For others in which the drug does not work then combination therapy or use of another agent alone may prove to be benificial for the patient. As an example, I have provided a quote for the URL that you listed for me.

"In many of the studies, of both fixed dose and titration designs, daily diaries were kept by patients. In these studies, involving about 1600 patients, analyses of patient diaries showed no effect
of VIAGRA on rates of attempted intercourse (about 2 per week), but there was clear treatment-related improvement in sexual function: per patient weekly success rates averaged 1.3 on 50-100 mg of VIAGRA vs 0.4 on placebo; similarly, group mean success rates (total successes divided by total attempts) were about 66% on VIAGRA vs about 20% on placebo. During 3 to 6 months of double-blind treatment or longer-term (1 year), open-label studies, few patients withdrew from active treatment for any reason, including lack of effectiveness. At the end of the long-term study, 88% of patients reported that VIAGRA improved their erections.

Basically, we are dealing with the definition of what constitutes success and is an "improved erection" enough of an erection to satisfy the patient. That is why you see the figures 30-50% of males for which Viagra is not efficacious bantered about. People are not exactly sure where the cut-off is yet.
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