Here's a broad STATs patent issued last month (to Rockefeller - which LGND has rights to):
United States Patent
5,716,622
Darnell, Jr., et. al.
Feb. 10, 1998
Functionally active regions of signal transducer and activators of transcription
Inventors:
Darnell, Jr.; James E. (Larchmont, NY); Wen; Zilong (New York, NY); Horvath; Curt M. (New York,
NY); Zhong; Zhong (New York, NY).
Assignee:
The Rockefeller University (New York, NY).
Appl. No.:
369,796
Filed:
Jan. 6, 1995
Intl. Cl. :
A61K 39/385, C07K 14/715, C07K 17/02
Current U.S. Cl.:
424/185.1; 424/193.1; 530/350; 530/403
Field of Search:
530/350, 403; 424/185.1, 193.1
References Cited | [Referenced By]
Foreign Patent Documents
WO 93/19179
Sept., 1993
WO
Other References
Darnell et al., 1994, Science 264:1415-1421.
Improta et al., 1994, Proc. Natl. Acad. Sci. USA 91:4776-80.
Shuai et al., 1994, Cell 76:821-28.
Zhong et al., 1994, Proc. Natl. Acad. Sci. USA 91:4806-4810.
Zhong et al., 1994, Science 264:95-98.
Eck et al., 1993, Nature 362:87-91.
Felder et al., 1993, Mol. Cell. Biol. 13:1449-55.
Khan et al., 1993, Proc. Natl. Acad. Sci. USA 90:6806-10.
Muller et al., 1993, EMBO J. 12:4221-28.
Muller et al., 1993, Nature 366:129-35.
Pearse et al., 1993, Proc. Natl. Acad. Sci. 90:4314-18.
Sadowski et al., 1993, Nature 362:79-83.
Sadowski et al., 1993, Science 261:1739-44.
Shuai et al., 1993, Nature 366:580-83.
Shuai et al., 1993, Science 261:1744-46.
Songyang et al., 1993, Cell 72:767-78.
Watling et al., 1993, Nature 366:166-70.
Wegenka et al., 1993, Mol. Cell. Biol. 13:276-88.
Schindler et al., 1992, Proc. Natl. Acad. Sci. USA 89:7836-39.
Schindler et al., 1992, Science 257:809-13.
Decker et al., 1991, EMBO J. 10:927-32.
Lew et al., 1991, Mol. Cell. Biol. 11:182-91.
Fu et al., 1990, Proc. Natl. Acad. Sci. USA 87:8555-59.
Wagner et al., 1990, EMBO J. 9:4477-84.
Primary Examiner: Chan; Christina
Assistant Examiner: VanderVegt; F. Pierre
Attorney, Agent or Firm: Klauber & Jackson
Abstract
The present invention relates generally to intracellular receptor recognition proteins or factors, termed Signal Transducers and
Activators of Transcription (STAT), to methods and compositions utilizing such factors, and to the antibodies reactive toward
them, in assays and for diagnosing, preventing and/or treating cellular debilitation, derangement or dysfunction. More
particularly, the present invention relates to particular functional domains of molecules that exhibit both receptor recognition and
message delivery via DNA binding in receptor-ligand specific manner, i.e., that directly participate both in the interaction with
the ligand-bound receptor at the cell surface and in the activity of transcription in the nucleus as a DNA binding protein. The
invention likewise relates to the antibodies and other entities that are specific to the functional domain of a STAT protein and
that would thereby selectively modulate its activity.
16 Claims, 31 Drawing Figures
The research leading to the present invention was supported by National Institute of Health Grant Nos. AI34420 and
AI32489. Accordingly, the Government may have certain rights in the invention. |
