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Biotech / Medical : Ligand (LGND) Breakout!

LGND 191.75

+1.0%

3:59 PM EST

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To: WTDEC who wrote (16670)	3/7/1998 9:42:00 AM
From: Henry Niman	of 32384

Here's a JAK/STAT review: Science 1994 Jun 3;264(5164):1415-1421 Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Darnell JE Jr, Kerr IM, Stark GR Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021. Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific DNA elements, and direct transcription. Recognition of the molecules involved in the IFN-alpha and IFN-gamma pathway has led to discoveries that a number of STAT family members exist and that other polypeptide ligands also use the Jak-STAT molecules in signal transduction. Publication Types: Review Review, tutorial PMID: 8197455, UI: 94255764

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