| Here are my, uh, thoughts a couple weeks old.  If they answer your question, great! 
 1/08/07
 
 TRGT
 
 Price:		$9.00
 MC:		$180m
 c/s:		19.1m  (7/06)
 Cash:		$68m est at 12/06. (Includes azn $20m milestone)
 Burn:		$24m in 2006
 IPO:		$9/sh on 4/18/06, post-IPO value was $172m.
 
 Summary of value ($130m)
 
 1.  TC-1734 (a/k/a AZD3480), for AD and cognitive enhancement in schizophrenia.  It has been in P2 and looks safe. AZN elected 12/06 to take it forward.  Stepped low double digit royalty.  $80m.
 
 2.  TC-2696.  P2 in acute post-operative pain commenced 12-06.  Doesn’t sound promising to me.  $0m.  The randomized, double-blind, single-dose trial is being conducted in the United States and is expected to enroll approximately 150 molar extraction patients. The trial includes five arms, 10, 25 and 50mg TC-2696, ibuprofen (400mg) as a positive control and placebo.
 
 3.  TC-2216, a product candidate for depression and anxiety disorders  and other indications, such as obesity. P1 began 1/8/07.  $40m.
 
 4  TC-5619, a preclinical product candidate selective for NNR  alpha7, b/u to x1734, with potential for schizophrenia, cognitive impairment and inflammation should be in P1 1H07.  $10m.  Add $30m when in the clinic.
 
 5.  TC-5214.  Not sure whether the top-line p2 results using mecamylamine hydrochloride are sufficiently robust to now take this, one of the enantiomers of mecamylamine hydrochloride, forward. $0m.
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