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Biotech / Medical : Indications -- Lupus/Nephritis
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To: scaram(o)uche who wrote (20)4/24/2001 3:49:03 PM
From: keokalani'nui  Read Replies (1) of 95
 
Rick. There is much in your message to gnaw on. Thank you. I've been in and out of T/TIF on more than one occaision, but it makes me feel kinda d-u-m-b. But in a good way. <g>

A confession about my passion. My interest here is to understand more about this therapeutic opportunity, especially (selfishly) as it relates to 5g1.1. With membraneous nephritis the next, or second (after aMI), alxn data set, I want to understand the explanation of endpoints when it comes (though I think it is only proteinurea and complement measurements) and the competitive landscape. Why not a collaborative experiment on SI?

(Little qualifier) so far, (big qualifier) to me, CLAa-Ig looks like the class of the field. Spin it may be, but ljpc has put a pretty good one on what looked like a train wreck not long ago. Finding a lot of p < .05 after buying a Biacore and re-dredging the data. I do have some instincts--the way ljpc couches their 10K business plan in terms of a drug platform makes me hold my nose.

>>I'm not saying that this subset of patients won't benefit from therapy.<<

Company says 90% of its PII and PII/III patients are the subset. Haven't looked into whether that would be representative of the population. Don't even know what dsDNA is!

As always, thanks for the pointers.

Wilder
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