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Biotech / Medical : Biotech Valuation
CRSP 57.37+0.9%3:59 PM EST
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To: IRWIN JAMES FRANKEL who wrote (23734)5/22/2007 10:59:07 AM
From: CrazyPete  Read Replies (1) of 52153
 
Cougar3's pooled analysis is not a valid method for combining data across experiments with different sample ascertainment. There are good reasons why the standard meta-analytic method is to combine the odds ratios rather than pooling the underlying counts.

You can easily construct situations where every study has an odds ratio > 1 but the combined counts give a value < 1, and Cougar3's analysis is really a demonstration of this flaw. NEJM is not stupid and the statistics in this paper would have been carefully vetted.
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