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Biotech / Medical : ArQule
ARQL 20.000.0%Jan 16 4:00 PM EST

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To: ahhaha who wrote (281)8/5/1998
From: Dr. Voodoo   of 399
 

"You pursue money and if the truth happens to be going in that way, you may visit it too... In biophysics or chemistry that's almost impossible to do because everything is inconceivably difficult and murky.

I pursue probability. Like the probability that what you say is nonsense is probably close to 99.9999999999999999999999999% and in about a zillion years some of your predictions will ring 100% true. I think you should replace inconceivably with "inconceivable" and difficult and murky with "to me!" and you'll have it ;-)

As far as bacterial resistance is concerned, much is confined to hospitals and a little of it(but very significant and very threatening as far as science is concerned) is community acquired. The likelyhood that resistant strains of bacteria that could thrive and endanger our population is significant. Yet for most infections, the same old drugs that have been around for years are effective. For instance sulfa drugs are still used to treat urinary tract infections.

You like to find the exceptions to rules to make your points, what you fail to take into account is the likelyhood of you're own hypothesis. I know plenty a scientist like you, you look for the hay in the haystack, and each straw you call a needle. This is junk science.

You're continued efforts to obscure the central point with useless information bores me. You still have not demonstrated any knowledge of drug discovery, and your insistence that I am some kind of biochemist only belies your ignorance of the field. Perhaps a biochemistry course might help you understand the principals of drug design, and how people find biological targets?

Just how do you design into a molecule such unanticipable circumstances?

Unanticipable is the problem. You fail to understand the reality of dealing with living organisms, whose main objective in life is to live.

Intelligent organisms learned along time ago to understand the mechanisms of resistance and get busy making more stuff to circumvent them. They have anticipated what you call unanticipable, by understanding how organisms survive. RT,protease, integrase, inhibitors of HIV are a good example.

Precisely the reason why companies like Arqule collaborate with others to go after new and unique targets with new and unique molecules.

Please tell me how a a group of individuals who don't know about the implications of a certain research can sit in judgement about the accuracy of what is presented?

You speak in the third person, and with a seemingly large chip on your shoulder. Does this mean you have not participated in the peer review process? I thought you were a scientist?

"You can hide in what isn't known, but don't bet someone else's life on it."

If I were the someone else, sick and dying of HIV, I'd take that bet every single day because IMO it's better than the alternative and the data is incontrovertible. But I guess in your time frame what's a few years? And is your profession the noblest of them all?

"When I find this type in my specialty I go out of my way to expose their fraudulence on a technical basis."

I'm a medicinal chemist. I make drugs.

What's your specialty?

"They are built up with false power from pseudo-science and that has become the scourge of the 20th century. It is called scientism."

Yup that's what I thought. The whole 20th century was nothing but a SCOURGE! I suppose I'll have to get back to typing email on my mathematical theorems.... Jeeze you crack me up, I guess that's why they call you AHHAHAHHAHAHHHAAA!



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