Agouron Pharmaceuticals (AGPH) Message Board

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Biotech / Medical : Agouron Pharmaceuticals (AGPH)

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To: Oliver & Co who wrote (2769)	11/16/1997 5:34:00 PM
From: BriBear	Read Replies (1) of 6136

Integrase inhibitor: ARNX is working on one... biz.yahoo.com Once the reverse transciptase enzyme has transposed HIV RNA into a DNA strand, integrase takes that strand & integrates it into the cellular DNA; then viral replication can begin. It seems to me that a down side to an integrase inhibitor is that it has a very narrow window to work within - after transcription & before integration. NRTIs & NonNRTIs stop the transcription process, PIs stop the assembly process of new virus particles. However, Aronex Pharmaceuticals (ARNX) has one entering Phase 2/3 trials soon & their price has been rising... Dr. Oliver: Do NonNRTIs work by binding with RT or as chain terminators?

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