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Biotech / Medical : Biotech Valuation
CRSP 57.37+0.9%Dec 8 3:59 PM EST
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To: Doc Bones who wrote (2858)2/9/2001 7:28:46 AM
From: Jim Oravetz   of 52153
 
Here is the Duke PR: COGNITIVE DECLINE AFTER BYPASS SURGERY PREDICTS FIVE-YEAR COGNITIVE DETERIORATION

DURHAM, N.C. -- While coronary artery bypass graft surgery has saved the lives of millions of Americans since its inception decades ago, physicians have long noticed a nagging problem -- many patients, while restored to good health, have noticed declines in their cognitive abilities....

....The Duke team is investigating many strategies to better understand this phenomenon of cognitive decline with the hope of developing new strategies to protect the brain. These include:

-- Using minimally invasive techniques, surgeons are now operating on beating hearts, meaning that the heart-lung machine is not needed. Preliminary results are encouraging, although the long-term effects are not yet known.

-- Duke researchers have found that temperature has an effect on cognitive decline. During surgery, the heart-lung machine cools the blood to lessen the metabolic needs of the body during the procedure. Duke studies have shown that patients who are rewarmed more slowly after surgery tend to do better on cognitive tests.

-- Duke researchers also have found a genetic component to the decline. Patients with the E-4 variant of the APOE gene (which has also been linked to early onset Alzheimer's disease) tend to do worse than patients with other variants of the gene.

dukenews.duke.edu

Jim
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