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Biotech / Medical : Quantech (QQQQ)
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To: John Zwiener who wrote (300)8/26/1998 11:09:00 PM
From: xyz  Read Replies (1) of 338
 
I am no longer with the company but I was the Director of Chemistry development at Quantech for 7 months of 1997. When I left the company they had not formalized their collaboration with Perkin Elmer (PE). A few months later they began to formally work together. The SPR system was not able to give any consistent results when I left the company. It is now apparent thanks to the vast optics expertise of PE that they have solved the basic problems with the stability of the instrument. The reason that myoglobin was the first assay to get approval is simply because it is the easiest. The concentration levels of this analyte in the blood are in the many 100's of nanograms per ml. For CKMB the sensitivity requirements are <1 ng/ml. I would say they are continuing to improve the performance of the system as they have started to collect data for the 510k on CKMB as explained in yesterday's press release. It may be entirely possible to continue and improve the system enough to measure Troponin I which must be measured at about 0.5 ng/ml. The difficult part of all this is also related to the fact that the analytes they are measuring are progressively smaller molecules. Myoglobin>CKMB>troponin. The spr system is based on measuring a change in mass near the surface of the gold grating where the signal is generated. When smaller molecules are being measured, they give less of a signal and it is more difficult to distinguish them from background noise. I am , however, interested in following the progress of Quantech as they are making rapid progress in my opinion. Since the spr technology is extremely versatile I think there may be some very promising things for Quantech in the future. They have had their problems in the past but It is starting to get pretty interesting now. I am not invested in them now but may consider it in the future if things continue to improve.

BTW:The way the system is set up(based on what I know from my experience over a year ago) it is likely that all three assays would incubate simultaneously and be read about the same time. The limiting factor would be the longest incubation which might be only 10-15 minutes or less.
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