Larry:
AP1903..... first, thanks Rudy, for informing me of the article.
I don't think much of the GvH effort. I think that they will be able to resolve the GvH, but that engraftment will go poof. It will boil down, IMO, to balanced use of transfected and normal marrow donations in an attempt to balance engraftment with a host's evolving capacities for protection. Messy.
I hope that I've missed something and that I'm flat-out wrong. I've been watching GvH since bone marrow Tx turned popular in the early 70's, and I was one of the first to conduct graft-versus-leukemia experiments (Fed. Proc. 35, 312). It's an ugly disease, and, since it is created by the clinician, it's always had an unethical side from my perspective.
It is very interesting, as an aside, that Berger mentioned the need for GvL in the article.
EPO and interferons, however? Go, ARIA!!
Rick |
