Agouron Pharmaceuticals (AGPH) Message Board

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Biotech / Medical : Agouron Pharmaceuticals (AGPH)

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To: BriBear who wrote (3480)	12/30/1997 8:55:00 PM
From: Miljenko Zuanic	Read Replies (1) of 6136

BB: You are bit confused by names. Nucleotide: DNA/RNA base (T, I, A, G, U, C,..) or their analogue + sugar (ribose) + phosphate ester. Nucleoside: DNA/RNA base + sugar Difference in one letter is for phosphorylated compounds. Also, any RT drug have to be phosphorylated (active metabolite in body) before they can do any inhibitory effects. Cidofovir (PMEA) and PMPA are phosphonylmethoxy base derivative and they do not have regular sugar component, or both drug are phosphorylated acyclic nucleotide. So this drug is already active inhibitor, compared to other RT drug. mz

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