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Biotech / Medical : Agouron Pharmaceuticals (AGPH)

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To: David S. who wrote (3721)	2/3/1998 7:13:00 PM
From: Oliver & Co	of 6136

"Docs Say AZT Thwarts Other AIDS Drugs" United Press International (02/02/98); Susman, Ed ÿÿÿÿ Jean-Pierre Sommadossi, a professor at the University of Alabama-Birmingham, announced at the Fifth Conference on Retroviruses and Opportunistic Infections in Chicago that AZT may actually hinder the effectiveness of new AIDS drugs.ÿ He suggested that chemical reactions caused by AZT could interfere with HIV fighting mechanisms, which could be a reason why HIV becomes resistant to AZT and other drugs in combination therapy. In his study, Sommadossi found a 95 percent reduction of viral levels in patients given d4T who had not previously taken AZT, while those who were first treated with AZT and then d4T registeredÿ only a 60 percent to 70 percent drop.ÿ Sommadossi suggests that AZT may interfere with phosphorylation--a process used by antiretroviral drugs to release their virus-fighting abilities--which could explain why patients do not show as positive reactions to therapy when their combination regimen includes AZT.ÿ Other studies presented at the conference, however, challenge Sommadossi's findings.

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