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Biotech / Medical : Agouron Pharmaceuticals (AGPH)
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To: JOHN W. who wrote (3770)2/8/1998 9:32:00 PM
From: Henry Niman   of 6136
 
John, I just uploaded the initial Reuter's story which seemed to indicate that the buffalo humps were associated with PIs in general not just Crix. The subsequent report named several PIs, supporting the first report. The per cent affect varies widely. Usually this discrepancy happens because the low numbers are from studies that don't look very hard, while the high numbers come from studies specifically looking for the condition. A good example would be phen/fen. Millions took the drug and no one really noticed the heart irregularities. When patients were subsequently tested, 1/3 had the defect. I suspect its the same for Buffalo Hump. If patients have been on a PI for a reasonable period of time (1 or 2 years), I suspect that the per cent will be much higher than 1%, and the condition will be associated with all PIs. Earlier characterizations of the condition as "insignificant" would be premature at best and grossly misleading at worst (actually the worst could be much stronger than grossly misleading).

As far as the cross resistance is concerned, I initially expressed surprise, base on the Jesse Eisinger article that came out several months ago. Your recent upload confirms my earlier posts. There is cross resistance (in the AGPH study, a significant per cent who started on Viracept and failed, were not able to achieve long lasting effects with subsequent PIs). The recent upload also fails to address my comments about time (I don't think that 24 weeks is a long time) and sensitivity (a detection limit of 500 copied per ml is not very sensitive).
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