United States Patent 6,458,775
Jackson , et al. October 1, 2002
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NAALADase inhibitors useful as pharmaceutical compounds and compositions
Abstract
The present invention relates to N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use to inhibit NAALADase enzyme activity, thereby effecting neuronal activities, inhibiting angiogenesis, and treating glutamate abnormalities, compulsive disorders, prostate diseases, pain and diabetic neuropathy.
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Inventors: Jackson; Paul F. (Bel Air, MD); Maclin; Keith M. (Baltimore, MD); Wang; Eric (Baltimore, MD); Slusher; Barbara S. (Kingsville, MD); Lapidus; Rena S. (Baltimore, MD); Majer; Pavel (Sykesville, MD)
Assignee: Guilford Pharmaceutical Inc. (Baltimore, MD)
Appl. No.: 346711
Filed: July 2, 1999
(no significance to this post.... just parking, just searching the patent positions relevant to "prostate-specific membrane antigen" usine "glutamate carboxypeptidase", and it's pointed to some surprising stuff IMO. I guess that recent progress with memantine hurts the NAALADase program, which I've long considered to be of interest??) |
