Here's the abstract from Rosenberg et al.
Science 1997 Nov 21;278(5342):1447-1450
Vigorous HIV-1-specific CD4+ T cell responses associated with control of
viremia.
Rosenberg ES, Billingsley JM, Caliendo AM, Boswell SL, Sax PE, Kalams SA, Walker BD
Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, and Harvard Medical School,
Boston, MA 02114, USA.
Virus-specific CD4+ T helper lymphocytes are critical to the maintenance of effective immunity in a number of chronic viral
infections, but are characteristically undetectable in chronic human immunodeficiency virus-type 1 (HIV-1) infection. In
individuals who control viremia in the absence of antiviral therapy, polyclonal, persistent, and vigorous HIV-1-specific CD4+ T
cell proliferative responses were present, resulting in the elaboration of interferon-gamma and antiviral beta chemokines. In
persons with chronic infection, HIV-1-specific proliferative responses to p24 were inversely related to viral load. Strong
HIV-1-specific proliferative responses were also detected following treatment of acutely infected persons with potent antiviral
therapy. The HIV-1-specific helper cells are likely to be important in immunotherapeutic interventions and vaccine
development. |
