DR DAVIS:
To my knowledge, the only downside of too many eggs is the large LDL-raising effect of the saturated fat in yolks, though it will also increase HDL.
I therefore believe that there is a balance to strike. If you have mostly small LDL and low HDL, I'd eat all the eggs you want. But if you are a very high large LDL person, then some restraint, e.g, several yolks per week, might be better.
We still lack confident data on the atherogenicity (plaque-causing potential) of isolated large LDL. While large LDL is clearly less harmful than small LDL, it remains unclear just how undesirable large LDL is.
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RE: "Invite K2 complex"
I wish I could shed some deep wisdom on the vitamin K2 discussion. However, as everyone is encountering, we quickly run out of real data and end up engaging in a lot of speculation.
Nonetheless, I believe that we can agree on several points about vitamin K2:
* Safety is probably not a big concern, given its occurrence in foods like cheese, meat, and especially natto (tens of thousands of milligrams). The only risk to eating natto is that you might vomit with disgust. (I've had it--it's positively awful.) In Japan, of course, the therapeutic dose of MK-4 as prescription Glakay starts at 15 mg (15,000 mcg) per day, with dose exploration studies extending up to 45 mg (45,000 mcg).
* The difficulty with studies like Rotterdam is that the design relied on diet surveys answered by participants and K2 content determined by estimating K2 content of foods. The best a study like this can provide is generation of an hypothesis; unfortunately, no matter how we twist, bend, or kick it, it cannot prove that K2 does or does not prevent heart attack. That has to wait further study. Also, it is unclear whether K2 itself provides benefit, or whether it simply serves as a marker for some other beneficial component of diet or behavior.
I remain excited about K2, but we sure need more data. Any doses I specify are simply speculative, certainly not based on a dose-escalation experiences in which we use increasing doses of K2, then observe the effect. But they are based on the best information available to date.
I remain uncertain on how much it adds to the TYP experience. But I do not believe that anyone is wasting their money by supplementing K2, since the data showing that it improves bone architecture and reverses osteopenia/osteoporosis is quite solid. |
