Sucralose is safe for human consumption when used in moderation.

Artificial sweeteners are attractive alternatives to sugar because they add virtually no calories to your diet. In addition, you need only a fraction compared with the amount of sugar you would normally use for sweetness.
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But according to the National Cancer Institute and other health agencies, there's no sound scientific evidence that any of the artificial sweeteners approved for use in the U.S. cause cancer or other serious health problems. And numerous research studies confirm that artificial sweeteners are generally safe in limited quantities, even for pregnant women. As a result of the newer studies, the warning label for saccharin was dropped.
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Although natural sugar substitutes may seem healthier than processed table sugar, their vitamin and mineral content isn't significantly different from that of sugar. Honey and sugar, for instance, are nutritionally similar, and both end up in your body as glucose and fructose. Choose a natural sweetener based on how it tastes and its uses, rather than on its health claims.

Is this 'natural' sweetener healthier than table sugar? (continued)One of the most celebrated properties of agave is its profile on the glycemic index, a scale that measures how much various foods raise blood sugar levels. Agave ranks lower than many other sweeteners on the glycemic index. As a result, some manufacturers tout it as a "diabetic friendly" sugar. But, according to Clemens, "there is inconsistent evidence to assign a glycemic value to any food, and it should not be used as a green light for diabetics."
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.In fact, the American Diabetes Association lists agave along with other sweeteners (table sugar, honey, brown sugar, molasses, fructose, maple sugar, and confectioner’s sugar) that should be limited in diabetic diets.

1. I don't argue with your great success.
2. I think trying to reduce my use of artificial sweeteners is just as good as trying to reduce how much pollution I contribute.
3. I believe your great success is mostly due to losing 100# and exercising not the addition of Agave, BUT I believe for you agave is a way to get "rewards" that makes sense for the diet you have selected. The "sugar pill" placebo effect is well known and documented.
4. It is hard to trust "studies" or anything the government tells us these days as we've seen from everything from being a felony to use the IRS to harass you for political beliefs. A good friend who did drug studies for big bucks at one time tells me very few will pay that sort of money to prove something is unhealthy unless they have an alternative they want approved...
   
5. The healthiest people I know usually don't have "dopamine issues" (easily addicted be it drugs or food) and they maintain healthy with a moderate diet that includes all foods, but in moderation.