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Biotech / Medical : TGEN - Targeted Genetics Corporation
TGEN 9.890+3.1%Oct 31 3:59 PM EST
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To: Mike McFarland who wrote (532)5/5/2008 2:45:34 AM
From: Mike McFarlandRead Replies (1) of 557
 
Metabolically Activated Recombinant Viral Vectors and Methods for Their Preparation and Use
www1.uspto.gov

A method for introducing a polynucleotide into a cell, comprising contacting the cell essentially in the absence of an AAV helper virus with a recombinant adeno-associated virus (rAAV) particle comprising an rAAV vector under conditions that allow uptake of the rAAV vector, whereby the rAAV vector is introduced into the cell, wherein the rAAV vector comprises a single-stranded heterologous nucleotide sequence comprising a coding region which forms intrastrand base pairs such that expression of the coding region of the heterologous sequence is enhanced relative to a second rAAV vector that lacks sufficient intrastrand base pairing to enhance said expression, wherein the rAAV vector comprises one or more inverted terminal repeat (ITR) sequence flanking said heterologous sequence.

(just filing it here)
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