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Biotech / Medical : A Good Cancer research Bio company?

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To: B. Ino who wrote ()	10/24/1996 11:16:00 PM
From: Jim R.	of 76

Hello: The best book I've found on Cancer breakthroughs is: Racing to the Beginning of the road:The search for the origin of Cancer (July 96)Rob't A. Weinberg founding member, MIT's Whitehead institute. A really good read + names the players. ISBN 0-517-59118-9 goes into the p53 gene, ras protein and tumor capillary killers (angiostatin). See last chapter for "circuit diagram" of cancer (p. 260) Cancer Co's I found: Merck, RPR, Onyx Pharm (ONXX) (Wrote an email on this: wwwicic.nci.nih.gov./jnci/issue24/86-1818.html GREAT SCI Am chart of the cancer lifecycle sciam.com Hi; I'm just finishing reading Racing to the Beginning of the Road: The Search for the origin of Cancer. (see the last chapter and P 260-261) It is (well) written by a founder of the Whitehead Institute in Cambridge and a good/thorough document on what is known of cancer. I've especially been doing some research on the theraputics involved with stopping tumors, shrinking growth, and detecting the efficacy of chemotherapy. I thought you might be interested. There seems to be a growing understanding of how tumors grow and highjack normal cell mechanisms; two things that seem to inhibit tumors are p53 (a gene) & ras inhibition. p53 seems to be a "critical predictor" of whether a cancer cell will respond to chemo; if the cells have normal p53 genes, they respond to chemotherapy by dying off. If p53 is mutated, the chemo doesn't work. Onyx Pharmicuticals (ONXX I think) is working on therapies based on this and has done human trials (they also went up 53% when news of this spread last friday). ras protein plays a central role in triggering human cancers; again, when mutated, it causes problems. It seems Merck and Rhone-Poulenc Rorer are working on ras-inhibitors. One other area pointed out was work being done on angiostatin (and AGM-1470) by Judah Folkman @ Children's Hospital (boston) on stopping growth of blood vessels into tumors. Hope that's what your looking for

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