In the Dauber ruling Matrixx attorneys ripped apart Alan Hirsch for being a quack because he promoted the theory that you could lose weight by smelling different scents. Alas please read the above where R. Steven Davidson and crew has a pear reviwed study confirming Hirsches scent theory. lol
Cant make this up. The Journal of Advanced Medicine publishes diploma mill degree theory. lol
slimscents.com
The Role of Specific Olfactory Stimulation in
Appetite Suppression and Weight Loss
Dr. S.N. Mayer, Dr. R.S. Davidson, and Dr. C.B. Hensley Human Neuro-Sensory Laboratory A
Division of BioTem Cytotechnologies
BioTem Cytotechnologies clo Best-Sellers Publishing Group 4200 Wisconsin Avenue N.W.. Suite 106-201
Washington, DC 20016
More than 30% of American adults age 20 and older are overweight (I, 2). Obesity is
a serious, chronic disease of epidemic proportions in the United States and is second
only to smoking as a risk factor for disease (3). Obesity increases the risk for a
number of serious and often fatal comorbid diseases such as non-insulin dependent
diabetes mellitus (NIDDM), dyslipidemias, cardiovascular disease, gallbladder
disease, osteoarthritis and some forms of cancer such as colon and post menopausal
breast cancer (4, 5). Approximately 300,000 deaths each year are attributed to
obesity, with obesity and its related diseases costing the American health care
system between 40 and \00 billion dollars annually (3,4,6). A recent estimate placed
the direct economic costs of obesity at more than 5.5% of all medical expenditures
(6).
Medical studies have shown that even a modest weight loss of only 10% can
significantly reduce obesity-related diseases (7). Yet, despite the fact that over 40%
of women and 24% of men in the United States are trying to lose weight, spending
over 30 billion dollars annually on weight reduction products, services and
programs, less than 5% are actually successful in achieving long-term weight loss. In
the last decade or so, there has been a 30% increase in the number of overweight
Americans, a greater increase than any past decade (1,8). Obviously, the myriad of
methods used to treat obesity, often involving complicated eating regimens, dietary
restrictions and deprivation and even prescription medication, have been
unsuccessful in the long term and sometimes even dangerous. Even so, Americans
continue to fight the war against excess weight.
One method which seems promising is the role of olfaction in weight regulation.
Specifically, the inhalation of positive hedonic (pleasant smelling) scents has been
shown to have beneficial effects on appetite and hunger regulation (9, \0, 11). This
idea stems from everyday observations of how food aromas affect appetite and from
clinical observations of how patients with acute anosmia often gain weight. These
observations suggest a breakdown in an olfactory satiety feedback mechanism. Also,
there are scientific EEG and brain mapping studies documenting the effects of the
inhalation of particular food scents on brain wave activity (12, 13, 14, 15).
The hunger-satiety cycle is regulated by a variety of interacting factors.
Psychological, social and environmental factors, nutrients and metabolic processes
and gastric movements initiate hunger Signals. Eating (along with associated
sensory processes), in turn, activate inhibitory signals leading to satiety. Because of
the inherent delay between the swallowing of food and the digestion of food, a
short-term Signal other than preabsorptive and postabsorptive humoral and neural
mechanisms is required (16). It is not simply the digestion of food or physical
stomach distention that allows the brain to determine a sense of fullness. Rather, it
is a variety of factors which include the aromas of food detected by olfactory
receptors that convey messages of how much food has been consumed to the
appetite control center of the brain (9, 10,17).
The anatomical/physiologic mechanisms of olfactory-induced satiety is complex.
This olfactory-satiety feedback mechanism is a result of direct anatomical
connections between the olfactory bulb and the ventromedial nucleus of the
hypothalamus, the satiety renter (18). Ambient scents are detected by olfactory
receptor cells, bipolar neurons that can distinguish over 10,000 different volatile
aroma molecules. The axons of these receptor cells synapse directly with neurons in
the olfactory bulb (17, 19). The olfactory bulb is a unique structure because it is
actually an outgrowth of the brain and contains almost all of the neurotransmitters
found in the rest of the brain including cholecystokinin and somatostatin,
gastrointestinal hormones known to control hunger and satiety (20). Recently, it has
been demonstrated that the dorsmedial thalamus plays a role in the hedonic
perception of food, and that lesions within this region of the brain result in
alteration in appetite and loss of weight (21). In addition, anatomical and
physiologic results clearly establish a functional/anatomical link between
processing of olfactory and visual information in the orbitofrontal cortex of the
brain and the control of feeding related behavior (22). These studies indicate that
central processing of hedonic clues is important in the short-term regulation of food
intake and thus long-term control of body weight.
These new insights into the mechanism of hunger and satiety provide a new
approach to an old problem of weight regulation. It is clearly evident that the sense
of olfaction via this olfactory-satiety feedback loop has a powerful and immediate
effect on appetite regulation. A recent medical study investigated the hypothesis
that intentionally inhaling specially formulated, positive-hedonic scents would
facilitate weight loss in overweight subjects. In this study, simply inhaling specially
formulated scents without any conscious changes in diet or lifestyle, subjects
sustained an average weight loss of 2% of body weight per month (4.7 pounds per
month) over a six month period (10).
The goals of this present study were to extend these observations and further test
the association of the inhalation of the same, specially formulated scents and weight
reduction in a double blind, randomized, controlled study to rule out any placebo
effects that may have been at work in the above study. This study tests the
hypothesis that inhalation of specially formulated, positive-hedonic scents can
function in the acute regulation of appetite and contribute to satiety. We also test
the hypothesis that the inhalation of positive hedonic scents can lead to sustained
weight loss. Finally, this study was designed to delineate the time course and rate of
weight loss.
Materials and Methods
Subjects
Phase one: 80 subjects participated in phase one of the double blind study (36 male
and 44 female; ages 18 - 43). Healthy adult volunteers who were at least ten pounds
overweight, indicating a desire to lose weight, and with no history of asthma were
enrolled in the study. Potential subjects responded to flyers posted at a local
university, were screened for the above criteria and were assigned by prior
computer randomization to receive either specially formulated scents or placebo
scents. The average height and weight of the subjects was 5'3" and l361bs. (range
110-185) respectively for females and 5'10" and l891bs. (range 165-220)
respectively for males.
Phase two: 30 healthy adult volunteers (9 male and 21 female) with no history of
asthma participated in phase two of the study. Potential subjects responded to flyers
posted at a local university, were screened for the above criteria and were assigned
by prior computer randomization to receive either specially formulated scents or
placebo scents.
Materials
The same specifically formulated scents, which have been shown in previous studies
by Dr. Alan Hirsch to have an effect on appetite control (10), were provided to each
subject in a convenient and practical vehicle (pens). It should be noted that humans
are capable of discerning greater than \0,000 different scents and thus olfaction has
the potential to provide a wide array of physiologically relevant stimuli. Placebo
Scents were developed and supplied by Biotem Cytotechnologies Inc. The placebo
pens were exact replicas of the pens containing the specially formulated scents but
did not contain these scents and were impregnated with a detergent scent, Both
pens containing the specially formulated scents and placebo scents were collected
and evaluated for use (remaining scent and pen weight) as a measure of compliance.
Protocol
Phase one: 80 subjects were provided with the Diet Pens (n=40) or placebo pens
(n=40). Each set of test pens contained 3 different scents which were used in an
alternate fashion. Each subject received 6 sets of pens and were instructed to
change to a new set every 3 weeks or until the scents began to significantly
diminish, which ever occurred first. Subjects were instructed to inhale the scents in
each nostril three times for three repeating cycles, 5-6 minutes prior to eating and
again within 5-6 minutes after eating. Subjects were instructed 10 use the pens
containing the specially formulated scents or those containing placebo scents before
meals, snacks, or whenever they felt the urge to eat. The investigators and subjects
did not know which subjects received devices containing the active ingredients. The
subjects were instructed not to overtly alter their normal routine of exercise or food
selection. Subjects were weighed each week for a duration of sixteen weeks.
Subjects were questioned at the end of the study regarding their impressions of the
effects of the pens on appetite and food consumption.
Data were collected manually, reduced and analyzed for statistical significance by
two tail Student's t-test. An alpha level of P less than or equal to 0.05 was used for
defining statistical significance of differences between treatment groups.
Phase two: 30 Subjects were recruited for phase two of the study. The subjects were
provided with the pens containing specially formulated scents (n=15) or placebo
scents (n=15). After subjects were presented with olfactory and visual stimuli (a
slice of pizza), they were instructed to rank their appetite cravings on a 1-10 scale.
Subjects were instructed to inhale the scents from one pen in each nostril three
times for three repeating cycles. The subjects were again asked to rank their
appetite cravings (1-10) 1 and 5 minutes after smelling the pens. The data were
tabulated and the significance of the difference were determine by two tail Student's
t-test.
An alpha level of P less than or equal to 0.05 was used for defining statistical
significance of differences between treatment groups.
Results
Subjects using the pens containing the specially formulated scents lost an average of
19.151bs. (11.68% of body weight) compared to placebo scents (3.85 Ibs.; 2.43% of
body weight) over the 16 week period (Tables 1-3; Figures 1-4). This translates to
an effective weight loss of 15.4 Ibs. (9.34% of body weight) in subjects using the
pens containing the specially formulated scents which was significant at the 99%
level of confidence (P less than 0.01). The rate of weight loss over time was slightly
sigmoid showing the greatest amount of effectiveness during the middle third of the
study (Tables 1-2; Figures 1-2).
Experiments designed to test the efficacy of the specially formulated scents as an
acute appetite suppressant demonstrated that the use of the pens containing the
specially formulated scents blunted the olfactory/visual stimulated appetite by 35.1
% in 1 minute and 49.25% in 5 minutes and both results were significant at the
99.9% level of confidence (Table 4) (P less than 0.001) when compared with
placebo (no reduction in appetite after 1 and 5 minutes).
Conclusions
This study confirms the results of a previous study "Weight reduction through
Inhalation of Odorants" by Drs. Hirsch and Gomez (10), that the inhalation of certain
aromas can aid in appetite control and weight loss and were not just a behavioral
response or an effect of being in a study. This study conclusively proves in a
randomized, controlled, double-blind fashion that the inhalation of specially
formulated scents are effective in appetite reduction, squelching food cravings and
weight loss without any conscious dieting or exercising.
Subjects using the pens containing the specially formulated scents as a weight loss
tool were able to lose a significant amount of weight over the course of the study,
while subjects using the placebo version did not see a significant degree of weight
loss. Given that the only difference between the pen containing the specially
formulated scents and the placebo was the presence of specific olfactory stimuli, the
increased weight loss is attributable to the specially formulated scents themselves.
The rate of weight loss was fairly consistent throughout the study demonstrating a
lack of habituation to scents over time. This is an important consideration when
dealing with olfactory/neural mechanisms.
In addition to affecting appetite and. inducing weight loss, this study also shows that
the specially formulated scents are very effective in blunting food cravings. Use of
the pens containing the specially formulated scents decreased the cravings for food
by 35% within one minute and 50% within five minutes. This effect was
significantly greater than what was seen with the placebo scents indicating that the
majority of the effect was attributable to the specially formulated scents. These
results suggest that acute appetite suppression is, at least in part, a viable
mechanism for the observed effects of the specially formulated scents on weight
loss. This is supported by the fact that subjects using the pens containing the
specially formulated scents reported an earlier and an increased sense of satiety
while eating. The subjects also reported that they were eating less during the meal
and were able to curb snaking by using the pens containing the specially formulated
scents.
In conclusion, this study demonstrates that the inhalation of specially formulated
scents harnesses the body's internal appetite control mechanism, the olfactorysatiety
feedback loop, by delivering specially formulated, positive hedonic
(pleasant) scents triggering the satiety center of the brain without the actual
consumption of food. The sense of smell enables the brain to determine a sense of
fullness by translating the amount of smell that reaches the olfactory cells into a
proportional amount of food one has presumably eaten before any digestion has
taken place. Thus inhaling the specially formulated scents, in the absence of food,
causes early satiety, squelches food cravings and decreases appetite by "fooling" the
brain into thinking that one has eaten a proportional amount of food. In the end, this
process turns off hunger, helps the user to stop eating sooner and thus controls the
amount of food consumed - a direct link to caloric consumption. This study
conclusively proves that inhaling these specially developed scents results in weight
loss without any conscious changes in diet or exercise
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