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Biotech / Medical : Agouron Pharmaceuticals (AGPH)

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To: Henry Niman who wrote (6023)2/1/1999 10:27:00 AM
From: Oliver & Co   of 6136
 
Some AIDS Patients Restored by Drugs Suddenly Decline"
Wall Street Journal (www.wsj.com) (02/01/99) P. B1; Tanouye,
Elyse
Despite the initial success of AIDS drugs to reduce viral levels
to below detectable levels in many patients, researchers say an
increasing number of patients who have benefited from the drugs
for several years are developing resistance to the drugs and
experiencing an increase in viral levels. Indeed, findings set
to be presented at an AIDS conference in Chicago show that only
about two-thirds of patients using a drug regimen including
Merck's Crixivan had very low levels of virus copies in their
blood after three years, compared with about 90 percent of
patients earlier in the study. Researchers have said they did
not expect the drugs to be effective forever, but they cannot
explain why some patients are suddenly not responding. One
theory suggests that the low viral levels in the body trick the
immune system into thinking the threat is gone and that the body
stops fighting the virus.
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