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Biotech / Medical : Immunomedics (IMMU) - moderated
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To: EMU2 who wrote (62922)11/21/2024 8:49:23 PM
From: stockdoc776 Recommendations

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I don't recall there ever being a claim that the vaccine would provide 100% protection against infection. The P3 data showed dramatic protection against serious illness and death, and that has held up quite well. What we didn't know was whether vaccination would be lifelong protection, or only seasonal. We also did not understand the capacity of the virus to mutate (Omicron anyone?). Unlike flu, the mutations were never enough to completely overcome vaccination, but it did make people susceptible to infection. Those infections for the vast majority were mild upper respiratory illnesses that resolved on their own. But the ICUs emptied out. There also appears to be some degree of immune attenuation with time (we see this with tetanus, which is why you get a booster when you go to urgent care having scraped yourself with a rusty nail). I can't remember the last time I had a patient with a true COVID pneumonia in the hospital. Omicron was so infectious that basically everyone who was not vaccinated got it, so we ended up with a population that was either immune from prior vax or prior infection, or both. I did not get COVID for four years, till I went to the Super Bowl in Vegas last February. There is clearly some natural variation in the receptor binding site that COVID uses to infect us, and it makes sense that some people just naturally have a binding site that doesnt line up with the COVID virus rendering you naturally immune. There are some people who are naturally immune to HIV due to a missing CCR5 gene (about 10% of Europeans are heterozygous for this, and 1 in 400 are homozygous and naturally HIV immune). There have been a few people cured of HIV because they got a bone marrow transplant from a CCR5 deficient donor to treat their leukemia. There is still a lot we don't know about the virus, and we are unsure as to how many COVID vax people should get. Should be like the flu and given every year? Or at some point have we vaxed enough? I think the latter is more likely true. There has been some work done on a universal coronavirus vaccine, that would be a good tool to have for a future pandemic. So would a universal flu vax.
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