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To: skinowski who started this subject	10/12/2001 10:41:33 PM
From: skinowski	of 17649

Given the rapid course of symptomatic inhalational anthrax, early antibiotic administration is essential. A delay of antibiotic treatment for patients with anthrax infection even by hours may substantially lessen chances for survival. Given the difficulty in achieving rapid microbiologic diagnosis of anthrax, all persons with fever or evidence of systemic disease in an area where anthrax cases are occurring should be treated for anthrax until the disease is excluded. Doxycycline is the preferred option from the tetracycline class of antibiotics because of its proven efficacy in monkey studies and its ease of administration. Other members of this class of antibiotics are suitable alternatives. Although treatment of anthrax infection with ciprofloxacin has not been studied in humans, animal models suggest excellent efficacy. In vitro data suggest that other fluoroquinolone antibiotics would have equivalent efficacy in treating anthrax infection, although no animal data exist for fluoroquinolones other than ciprofloxacin. jama.ama-assn.org

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