Bernard,
Here's the abstract, FWIW.
>>Cancer Res 2002 Apr 15;62(8):2239-43
Adenoviral Transfer of the Melanoma Differentiation-associated Gene 7 (mda7) Induces Apoptosis of Lung Cancer Cells via Up-Regulation of the Double-Stranded RNA-dependent Protein Kinase (PKR).
Pataer A, Vorburger SA, Barber GN, Chada S, Mhashilkar AM, Zou-Yang H, Stewart AL, Balachandran S, Roth JA, Hunt KK, Swisher SG.
Departments of Thoracic and Cardiovascular Surgery [A. P., J. A. R., S. G. S.], and Surgical Oncology [K. K. H., S. A. V.], The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030.
Adenoviral-mediated overexpression of the melanoma differentiation-associated gene 7 (Ad-mda7) induces apoptosis in a wide range of cancer cells, although themechanism is not well understood. We report that Ad-mda7 induces andactivates the double-stranded RNA-dependent protein kinase (PKR), which leads to phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2alpha) and the induction of apoptosis in lung cancer cells. Treatment with 2-aminopurine (2-AP), a serine/threonine kinase inhibitor, inhibits PKR activation, eIF2alpha phosphorylation, and apoptosis induction by Ad-mda7. Additionally, PKR null but not wild-type fibroblasts are resistant to Ad-mda7-induced apoptosis. These results suggest that the activation of PKR and its downstream targets may be a critical pathway for Ad-mda7-mediated apoptosis.<<
I had predicted GNVC would be in 2s after having BioBypass rights returned to it, and I missed that prediction by .01. It would appear TNFerade has saved it from that fate:
Message 17494144
Cheers, Tuck |
