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Biotech / Medical : Neuroscience
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To: tommysdad who wrote (72)9/27/2000 11:45:13 PM
From: scott_jiminez   of 278
 
tommysdad - there's quite a bit of evidence that estrogen has highly localized site(s) of activity (i.e. ER) and broader influences on multiple systems in the CNS. An example of a potential role for estrogen in Parkinson's disease ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10924688&dopt=Abstract

I'd be curious to know if you're familiar with any citations showing specific orphan-ER-like localization in brain.

Also - since I've not studied this much either - how does one take advantage of knowledge of an orphan GPCR (say orphan to a 'normal' cell surface receptor such as 5-HT1B or m1 muscarinic) in approaching a CNS pathology putatively involving that receptor?
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