| REDWOOD CITY, Calif., Feb. 9 /PRNewswire/ -- Anergen, Inc. (NASDAQ:ANRG) announced today that its collaboration with Novo Nordisk (NYSE:NVO) for
 AnergiX(TM) would be terminated, with all rights returning to Anergen.  Novo
 Nordisk will reimburse Anergen for the cost of the ongoing multiple sclerosis
 Phase I clinical trial.  The trial is expected to be completed in the third
 quarter of 1998.  The Company also announced that it will be restructuring its
 workforce to meet anticipated future needs in research and development.
 "Novo Nordisk has previously publicly disclosed its move away from
 research and development in the central nervous system arena.  Continuing the
 collaboration between the two parties did not seem to be in the best interests
 of either Anergen or Novo Nordisk," commented Barry Sherman, M.D., President
 and Chief Executive Officer of Anergen.
 "We continue to have a high regard for Anergen and its technology.  Our
 decision is based solely on changes in Novo Nordisk's strategic direction and
 not any lack of confidence in the AnergiX technology," remarked Dr. Claus
 Kuhl, President of ZymoGenetics, Inc., Novo Nordisk's U.S. research affiliate.
 Under the terms of the agreement, all rights return to Anergen and the
 Company will not have any future obligations to Novo Nordisk.  Therapeutic
 areas covered in the collaboration included multiple sclerosis, myasthenia
 gravis and Type I diabetes mellitus.
 "We view this as an important opportunity for Anergen to move forward in
 the development of our AnergiX products, and to find new corporate partners
 more closely aligned with our efforts in multiple sclerosis and other
 autoimmune diseases.  We will conclude the Phase I trial in multiple sclerosis
 and, pending a favorable outcome, begin planning for Phase II trials," said
 Dr. Sherman.  "Anergen will also restructure its operations to maintain our
 current burn rate, reducing our current workforce by approximately 15 persons.
 We are continuing our clinical development efforts with both AnergiX and
 AnervaX(TM), as well as emphasizing new research efforts for treating
 autoimmune disease."
 Anergen, Inc. is a biotechnology company focused on advancing the
 treatment of autoimmune diseases.  It is developing proprietary
 biopharmaceutical compounds designed to selectively interrupt antigen
 presentation or inactivate T cells in the immune system that mediate the
 disease process.
 NOTE:  Certain statements in this press release about the Company's
 utilization of resources, product development activities, clinical trials, and
 product pipelines, other than statements of historical fact, are forward
 looking statements, and are made pursuant to the Safe Harbor Provisions of the
 Private Securities Litigation Reform Act of 1995.  Such statements involve
 risks and uncertainties.  The Company's actual results could differ materially
 from the results discussed in these forward looking statements.  Factors that
 could cause or contribute to such differences include dependence upon
 collaborative partners for the advancement of the company's research and
 development activities and future requirements for additional capital.  These
 items are discussed in the Company's Form 10-K filed for fiscal year 1996 and
 the reports filed on Form 10-Q.
 SOURCE  Anergen Inc.
 -0-                             02/09/98
 /CONTACT:  David V. Smith, Vice President, Finance, and Chief Financial
 Officer, or Barry M. Sherman, M.D., President & Chief Executive Officer of
 Anergen, Inc., 650-361-8901; or media, Peter Steinerman of SBC, 516-374-3031,
 for Anergen, Inc.; or investors, Jonathan Fassberg of The Trout Group,
 212-477-9007, ext. 16, for Anergen, Inc./
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