T/FIF, a New Plateau Message Board

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Biotech / Medical : T/FIF, a New Plateau

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To: scaram(o)uche who wrote (756)	11/27/2001 1:21:46 PM
From: tuck	Read Replies (1) of 2243

Rick, Seems to me that bolded portion is saying they can modulate this ubiquitin ligase (among other things that seem beneficial, but maybe not -- this why you talk of other toxicities and await animal data?), via inhibition by tinkering with different parts of this SLAP-2 molecule. Indeed, I would think animal data is being generated now, next logical step at this point, IMO. I am anticipating this will be positive, but do you see any specific hints about toxicities from any of this so far? Thinking large shareholders may indeed lighten up, and some of them before X-Mas in an expected market pullback. I could see RIGL hitting lower mid 4s. I'll yell then (BLUE HP will be buying) and if I find preclinical stuff. Edit: No tyrosine kinase domain ==> combo therapy possibilities? Like EBIO under $2, but not very T/FIFish. Cheers, Tuck

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