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Biotech / Medical : Regeneron Pharmaceuticals

REGN 741.34

-1.2%

2:15 PM EST

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To: nigel bates who wrote (809)	5/19/2003 7:56:06 PM
From: Miljenko Zuanic	of 3559

Nigel, I do not believe that true problem for A is antibody or selection of the correct obesity population, early responders. GNSC, or anyone else can not help them. The problem is in Axokine dose, “1MCG/KG” selected as optimal dose (One big BS) , for something that has short plasma half life and it has to cross BBB, actually diffuse into hypothalamus. Also: “Additional exploratory analyses revealed that patients who appeared to benefit the most from either AXOKINE treatment or a weight reduction program alone were those subjects who lost at least 4 kilograms (8.8 pounds) after 3 months of therapy ("early responders").” I thought that HOT WATER was discovered bazzilians years ago? <g> But, to make think clear, in my view so far Axokine has the best target profile, only one need to find how to dose drug at therapeutic level, not sub-optimal. Miljenko

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