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Biotech / Medical : Biotech Valuation

CRSP 56.68

-2.4%

Dec 12 9:30 AM EST

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To: Biomaven who wrote (8353)	5/13/2003 8:49:32 PM
From: Biomaven	Read Replies (3) of 52153

I just couldn't resist, and went to PubMed. Sure enough: Science 1994 Aug 12;265(5174):956-9 Inhibition of NF-kappa B by sodium salicylate and aspirin. Kopp E, Ghosh S. Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06536. The transcription factor nuclear factor-kappa B (NF-kappa B) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs. This inhibition prevented the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B was retained in the cytosol. Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells. Peter

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