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Biotech / Medical : Geron Corp.
GERN 1.370-2.8%Jan 23 9:30 AM EST

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To: gmccon who wrote (78)8/15/1997 5:39:00 PM
From: Rob-Chemist   of 3578
 
I don't think that the shortening of telomeres is related to the major problems of aging, but I must stress that aging is an extremely poorly understood phenomenon. For example, dementia is a common symptom of aging. It is extremely unlikely that shortening of telomers is involved in dementia for the simple fact that, once you reach maturity, nerve cells undergo minimal further cell division and, therefore, no further shortening of telomeres. Likewise, it is difficult to see how telomere length is conditions such as hardening of the arteries. The immune system appears to become less able to respond to infections as one ages, and this might be related to telomere shortening. A key aspect of the immune response is rapid cell division, and loss of immune cells due to very short telomeres would compromise the rapidity and strength of an immune response.
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